Science Behind Oh!mino®

Truth Over Hype

The Science Behind Oh!mino

We don't build products because they're fashionable. We build them because they're backed by credible science — NASA-funded research, peer-reviewed studies, and 32 cited sources. Here's the evidence, not the marketing.

Muscle Protein Synthesis — Relative Effectiveness

Source: Journal of Experimental Gerontology, 41:2158–219, 20061

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BCAAs Whey Protein Oh!mino

11×1,5,6

more effective at stimulating muscle protein synthesis than whey protein

20×7

more effective than BCAAs alone

Axis scale is illustrative, matched to comparative muscle protein synthesis research — see references 1, 5, 6, 7. † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Why Essential Amino Acids, Not Whey or BCAAs

For years, the conversation around recovery has centered on protein powders — especially whey — and branched-chain amino acids. Research has continued to point at a piece that conversation was missing.

There are 20 amino acids in the body, in three categories: essential (nine your body cannot produce and must get from food or supplementation), semi-essential (six your body can produce under stress), and non-essential (eleven your body makes on its own).10 Muscle synthesis is most efficient when there are free essential amino acids available in the blood — and research indicates semi-essential and non-essential amino acids aren't necessary to get there.12,13

Most protein powders offer an incomplete amino acid profile, plus sugars and carbohydrates you don't need.9 BCAAs are only three of the nine essential amino acids — isoleucine, leucine, and valine.7 A 20-gram serving of whey contains roughly 8–10 grams of essential aminos; one scoop of Oh!mino delivers the equivalent of over 30 grams of protein in essential aminos alone — without the calories that work against free plasma amino acid concentration.5,14

A 3D render of an amino acid molecule structure in red

Combat Aging With Optimal Muscle Synthesis

Aging brings a steady decline in muscle mass and performance — known clinically as sarcopenia — driven largely by a decline in your body's rate of muscle protein synthesis.10 Muscle synthesis is one of the most fundamental things your body does: proteins are the building blocks not just of muscle, but of nearly everything that keeps you functioning.11

Proteins act throughout the body as:

  • Enzymes
  • Antibodies
  • Hormones
  • Messengers
  • Tissue structure
  • Transport molecules

Your body adapts to changes in protein intake, but it always needs a steady supply of the nine essential amino acids to keep muscle synthesis running the way it should.

NASA-Funded Research

Two studies. One question: what protects muscle when the body can't move?

Conducted by scientists at The University of Texas Medical Branch and supported by NASA — which needed a solution for muscle atrophy in astronauts during spaceflight.2,3 The findings apply just as directly to bedrest, illness, injury, and aging.

  • Essential amino acids produce a rapid, several-fold increase in plasma amino acid levels.
  • They stimulate muscle synthesis better alone than mixed into a meal with non-essential aminos.
  • Without added carbs or protein, the muscle synthesis response is even more potent — and won't spike insulin.
  • Supplementation preserved muscle mass through 28 days of bedrest.
  • One study found an actual increase in type 1 muscle fibers in the bedrest group taking essential amino acids.3

Most Effective Paired With Exercise

During normal activity, muscle breakdown and muscle synthesis roughly cancel out — the reason you don't waste away, and don't turn into a bodybuilder overnight. Research shows you can tip that balance in favor of synthesis by having free amino acids available in your plasma.14

The figure to the right, adapted from a published study, shows the effect clearly: amino acids alone shift net muscle balance from negative to positive at rest — and the effect is even larger when paired with exercise.16 That's the science behind taking Oh!mino before a workout: amino acids need to be available in the plasma directly after exercise, but consumed beforehand.

Figure showing the influence of amino acids on muscle protein net balance, adapted from Biolo et al.
Adapted from Biolo et al., as cited in reference 16. Reproduced for educational purposes.

Who Oh!mino Is For

Health-Conscious

Balanced essential amino acids your body needs at a higher rate as you age.17

Athletes

Faster recovery from the included adaptogens, plus full electrolyte support during training.8

Bodybuilders

Protein powders and BCAAs are only part of the puzzle — a complete essential amino acid profile is the rest of it.

Vegans & Vegetarians

Covers lysine, methionine, phenylalanine, and tryptophan — the aminos most often missing from plant-based diets.

Post-Surgery & Bedrest

The same NASA-studied ratios shown to preserve muscle mass during extended immobility.2,3

Elderly

Directly supports the muscle synthesis that naturally declines with age.14,15

Every Essential Amino Acid, and What It Does

Oh!mino's patented complex delivers 3,100 mg of all nine essential amino acids in an ideal ratio, plus glycine — the one semi-essential amino acid worth including.

EAA

Leucine

Weight management, healthy blood sugar, appetite regulation.18,19

EAA

Lysine

Repairs connective tissue; growth and repair of skin, muscle, tissue.20,21

EAA

Threonine

Forms collagen, elastin, and tooth enamel; supports mood and cognition.22

EAA

Valine

Supports liver health; involved in exercise-related serotonin release.23,24

EAA

Phenylalanine

Precursor to norepinephrine — alertness, mood, memory.25

EAA

Histidine

Tissue repair, myelin maintenance, digestion, immune health.26

EAA

Isoleucine

Detoxification, tissue repair, immune activation, blood sugar support.27

EAA

Tryptophan

Precursor to serotonin and melatonin — sleep, mood, stress resilience.28

EAA

Methionine

Healthy blood lipids, detoxification, skin, nail, and tissue support.29

Semi-EAA

Glycine

Cell-protective, immune-regulating, supports performance under sleep restriction.30,31

Fully Balanced Electrolytes

Most electrolyte products contain only the two cheapest electrolytes — sodium and potassium. Your body needs all five, in the right ratios, to move nutrients, regulate pH, and keep your brain, muscles, and heart working the way they should.32

Calcium Magnesium Chloride Sodium Potassium

Quality You Can Verify

Claims are only as good as what backs them. Oh!mino is manufactured under Current Good Manufacturing Practice (CGMP) certification and NSF certification — both requiring regular audits, FDA-compliant facilities, and verified sourcing.

CGMP Certified NSF Certified Vegan & Vegetarian Bio-Fermented Non-Dairy Zero Sugar / Carbs / Calories Non-GMO Gluten-Free Free of Major Allergens

How to Take Oh!mino

How you take Oh!mino depends on your goals, but the system is simple: powder with caffeine before training, stimulant-free powder for recovery, capsules on rest days.

Caffeinated Powder

100 mg pharmaceutical-grade caffeine. Best taken before a workout for a performance and energy boost alongside the amino acid complex.

Stimulant-Free Powder

Same complex, no caffeine. Ideal as a daily supplement, a post-workout recovery drink, or for anyone avoiding stimulants.

Capsules

Best for rest days or whenever you want the benefits without a drink mix or added caffeine.

References

  1. Journal of Experimental Gerontology. 41:2158–219, 2006.
  2. Paddon-Jones D, Sheffield-Moore M, Urban RJ, et al. Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. NCBI, NLM, NIH. ncbi.nlm.nih.gov/pubmed/15356032. September 2004.
  3. Fitts RH, Romatowski JG, Peters JR, et al. The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation. March 2007.
  4. Wolfe RR. Regulation of muscle protein by amino acids. NCBI, NLM, NIH. ncbi.nlm.nih.gov/pubmed/12368421. October 2002.
  5. Jackman SR, Witard OC, Philp A, et al. Branched-chain amino acid ingestion stimulates muscle myofibrillar protein synthesis following resistance exercise in humans. NCBI, NLM, NIH.
  6. Reidy PT, Walker DK, Dickinson JM, et al. Protein blend ingestion following resistance exercise promotes human muscle protein synthesis. The Journal of Nutrition. April 2013.
  7. Paddon-Jones D, Sheffield-Moore M, Katsanos CS, et al. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. NCBI, NLM, NIH. February 2006.
  8. Hou CW, Lee SD, Kao CL, et al. Improved inflammatory balance of human skeletal muscle during exercise after supplementation of the ginseng-based steroid Rg1. NCBI, NLM, NIH. January 2015.
  9. Miller SL, Tipton KD, Chinkes DL, et al. Independent and combined effects of amino acids and glucose after resistance exercise. March 2003.
  10. Rooyackers O, Adey D, Ades P, et al. Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. NCBI, NLM, NIH. 1996.
  11. What are proteins and what do they do? U.S. National Library of Medicine, NIH. 2018.
  12. Børsheim E, Tipton KD, Wolf SE, et al. Essential amino acids and muscle protein recovery from resistance exercise. NCBI, NLM, NIH. October 2002.
  13. Tipton KD, Gurkin BE, Matin S, et al. Nonessential amino acids are not necessary to stimulate net protein synthesis in healthy volunteers. NCBI, NLM, NIH. February 1999.
  14. Paddon-Jones D, Sheffield-Moore M, Zhang XJ, et al. Amino acid ingestion improves muscle protein synthesis in the young and elderly. NCBI, NLM, NIH. March 2004.
  15. Volpi E, Mittendorfer B, Wolfe SE, et al. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. American Physiological Society. September 1999.
  16. Wolfe RR. Skeletal muscle protein metabolism and resistance exercise. The Journal of Nutrition. February 2001.
  17. Hansen RD, Raja C, Allen BJ. Total body protein in chronic diseases and in aging. NCBI, NLM, NIH. May 2009.
  18. Leucine: PubChem Open Chemistry Database. NCBI, NLM, NIH.
  19. Pedroso JAB, Zampieri TT, Donato Jr. J. Reviewing the effects of l-leucine supplementation in the regulation of food intake, energy balance, and glucose homeostasis. NCBI, NLM, NIH. May 2015.
  20. Smriga M, Ando T, Akutsu M, et al. Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. NCBI, NLM, NIH. April 2007.
  21. Datta D, Bhinge A, Chandran V. Lysine: is it worth more? NCBI, NLM, NIH. August 2001.
  22. Threonine: PubChem Open Chemistry Database. NCBI, NLM, NIH.
  23. Nakanishi C, Doi H, Katsura K, et al. Treatment with L-valine ameliorates liver fibrosis and restores thrombopoiesis in rats exposed to carbon tetrachloride. NCBI, NLM, NIH. June 2010.
  24. Gomez-Merino D, Béquet F, Berthelot M, et al. Evidence that the branched-chain amino acid L-valine prevents exercise-induced release of 5-HT in rat hippocampus. NCBI, NLM, NIH. July 2001.
  25. Phenylalanine: PubChem Open Chemistry Database. NCBI, NLM, NIH.
  26. Histidine: PubChem Open Chemistry Database. NCBI, NLM, NIH.
  27. Isoleucine: PubChem Open Chemistry Database. NCBI, NLM, NIH.
  28. Tryptophan: PubChem Open Chemistry Database. NCBI, NLM, NIH.
  29. Methionine: PubChem Open Chemistry Database. NCBI, NLM, NIH.
  30. Zhong Z, Wheeler MD, Li X, et al. L-glycine: a novel anti-inflammatory, immunomodulatory, and cytoprotective agent. NCBI, NLM, NIH. March 2003.
  31. Bannai M, Kawai N, Ono K, et al. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. NCBI, NLM, NIH. April 2012.
  32. Shirreffs SM, Sawka MN. Fluid and electrolyte needs for training, competition, and recovery. NCBI, NLM, NIH. June 2011.

Full citations available upon request and signed Non-Disclosure Agreement.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Source: Oh!mino White Paper with References, 2018.